Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization.

We evaluated changes in the binding properties of sedative and non-sedative histamine H1-receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells. Internalization of H1 receptors was induced without their degradation by treatment with 0.1 mM histamine for 30 min at 37 degrees C, and then the intact cell binding assay was performed at 4 degrees C....

Pentazocine : a Study of Its Sedative Properties

The sedative effects of pentazocine 50 mg given orally have been studied in 100 healthy gynaecological patients using a standard scoring system. It was found that pentazocine produced mild sedation which was not significantly greater than that produced by a placebo in the numbers studied. The incidence of complications was low and while there was a higher incidence of postoperative nausea and v...

Effects of Sedative Medicines

تا سال ۱۹۵۰ داروی اختصاصی برای درمان نشانه های سایکوتیک در دسترس نبود. در سال ۱۹۵۲ برای اولین بار داروی کلرپرومازین در یک بیمارستان ارتش در حومه پاریس تجویز شد. دو سال بعد این دارو با نام «لارگاکتیل» در فرانسه مورد استفاده قرار گرفت. نام این دارو بازتابی از اثرات وسیع آن می باشد. کلرپرومازین با داروهای خواب آور ابتدایی مثل هیدرات کلرال و باربیتوراتهاه متفاوت بود، زیرا اثراتی بیش از خواب آوری دا...

Sedative antidepressants and insomnia.

OBJECTIVE The present review addresses the relationship between sleep and depression and how serotonergic transmission is implicated in both conditions. METHOD Literature searches were performed in the PubMed and MedLine databases up to March 2010. The terms searched were "insomnia", "depression", "sedative antidepressants" and "serotonin". In order to pinpoint the sedative antidepressants mo...

Sedative Treatment of Cholera